Endocrine Abstracts

Langherhans cell histiocytosis (LCH) and Erdheim-Chester (EC) are two histiocytic disorders which occurrence in the same patient has rarely been described. Thyroid involvement of LCH is rare, and concurrent papillary thyroid carcinoma (PTC) exceptionally reported. We report a case of a 73 year old man who presented a diagnosis of mixed histiocytosis LCH and EC. The patient suffered of insipidus diabetes since 1 year without pituitary abnormality but clinical examination showed...

Erdheim-Chester disease (ECD) is a rare histiocytic neoplasm with distinctive clinical and immunophenotypic features, involving somatic mutations of BRAF and activation of MAPK pathway. Other BRAF mutated neoplasms such as papillary thyroid carcinoma (PTC), may also occur synchronous with EDC. There are several reports in the literature of concurrent Langerhans Cell Histiocytosis (LCH) and PTC which suggests that the association is not random, howeve...